Isotopically Labeled Compounds
Medchemexpress LLC Amantadine-d6 | 1219805-53-4 | 98.1% | 5 MG
Amantadine-d6 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an orally active and potent antiviral agent effective against influenza A viruses. It inhibits various ion channels, including NMDA and M2, as well as Coronavirus ion channels. It also exhibits anti-orthopoxvirus and anticancer activities. Amantadine-d6 can serve as a tracer and an internal standard for quantitative analysis, with deuteration potentially influencing pharmacokinetic and metabolic profiles of drugs. Applications include research for Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes incorporated into drug molecules for quantitation
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Etidronic acid-d3 disodium | 358730-93-5 | 98.0% | 5 MG
Etidronic acid-d3 disodium is a deuterium-labeled form of Etidronic acid disodium, intended exclusively for research purposes. This compound serves as a valuable tool in quantitative analysis due to the potential of deuteration to influence pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Chlorpromazine-d6 hydrochloride | 1228182-46-4 | 99.9% | 1 MG
Chlorpromazine-d6 (hydrochloride) is the deuterium labeled Chlorpromazine. Chlorpromazine is an inhibitor of dopamine receptor, 5-HT receptor, potassium channel, and sodium channel. It is used for research purposes only and not sold to patients. This compound can be used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration, the incorporation of stable heavy isotopes into drug molecules, has potential to affect pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled Chlorpromazine
- Inhibits dopamine receptor, 5-HT receptor, potassium channel, and sodium channel
- Used as a tracer or internal standard for quantitative analysis
- Deuteration can affect pharmacokinetic and metabolic profiles
Medchemexpress LLC D-Glucose-d1-4 | 106032-61-5 | 98.0% | 100 MG
D-Glucose-d1-4 is the deuterium labeled D-Glucose. This monosaccharide is an important carbohydrate in biology, serving as a critical component of general metabolism and a significant signaling molecule for cellular metabolic status and stress response.
- Deuterium labeled D-Glucose
- Important carbohydrate in biology
- Critical component of general metabolism
- Significant signaling molecule
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Tolbutamide-d9 | 1219794-57-6 | 99.0% | 1 MG
Tolbutamide-d9 is a deuterium-labeled Tolbutamide. Tolbutamide is classified as a first-generation potassium channel blocker and a sulfonylurea oral hypoglycemic agent. This compound can be used as a tracer or an internal standard for quantitative analysis.
- Used as a tracer in drug development
- Serves as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes into drug molecules
- Deuteration may influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Erythromycin-d3 | 959119-26-7 | 95.0% | 1 MG
Erythromycin-d3 is a deuterium-labeled macrolide antibiotic produced by the actinomycete Streptomyces erythreus. It exhibits broad-spectrum antimicrobial activity by binding to bacterial 50S ribosomal subunits, thereby inhibiting RNA-dependent protein synthesis. Beyond its antibiotic properties, Erythromycin also demonstrates antitumor and neuroprotective effects in various research areas.
- Can be utilized as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Adenosine-1′-13C | 201996-55-6 | 96.3% | 1 MG
Adenosine-1′-13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology and is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes into drug molecules for quantitation
- Has potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Bromhexine-d3 hydrochloride | 611-75-6 | 99.0% | 1 MG
Bromhexine-d3 (hydrochloride) is a deuterium-labeled Bromhexine (hydrochloride) that functions as a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. It holds potential for preventing and managing SARS-CoV-2 infection and also acts as an autophagy agonist. Additionally, Bromhexine hydrochloride serves as a mucolytic cough suppressant, suggesting its utility in various respiratory conditions. This product is intended for research use only.
- Deuterium labeled Bromhexine (hydrochloride)
- Potent and specific TMPRSS2 protease inhibitor
- Can prevent and manage SARS-CoV-2 infection
- Autophagy agonist
- Mucolytic cough suppressant
- Used as a tracer or internal standard for quantitative analysis
Medchemexpress LLC D-Glucose-d12-1 | 89798-27-6 | 99.4% | 50 MG
D-Glucose-d12-1 is a deuterium-labeled D-Glucose. It is a monosaccharide, a crucial carbohydrate in biology, a carbohydrate sweetener, and a vital component of general metabolism. It also serves as a critical signaling molecule related to cellular metabolic status and biotic and abiotic stress responses.
- Can be used as a tracer.
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes into drug molecules for quantitation during drug development.
- Deuteration can potentially affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Biotin-d2 | 58-85-5 | 98.5% | 5 MG
Biotin-d2 is the deuterium labeled Biotin, an enzyme co-factor found in minute amounts in every living cell. This product is for research use only and is not intended for patient use.
- This compound can be utilized as a tracer.
- It serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- The incorporation of stable heavy isotopes like hydrogen and carbon into drug molecules, as seen with deuterium, is primarily for quantitation during drug development and has shown potential in influencing the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC 4,4'-((Pentane-1,5-diyl-1,1,5,5-d4)bis(oxy))dibenzimidamide dihydrochloride | 1276197-32-0 | 98.0% | 5 MG
This product is Pentamidine-d4 dihydrochloride, with a purity of 98.0%. It appears as a white to off-white solid. It has a molecular formula of C19H22D4Cl2N4O2 and a molecular weight of 417.37. It is intended for research use only.
- Appearance: White to off-white solid
- Purity: 98.0%
- Isotopic enrichment: 99.2%
- Molecular formula: C19H22D4Cl2N4O2
- Molecular weight: 417.37
- Store at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
Medchemexpress LLC Atorvastatin-d5 (sodium) | 222412-87-5 | 96.95% | 1 MG
Atorvastatin-d5 (sodium) is a deuterium-labeled Atorvastatin sodium. It acts as an orally active HMG-CoA reductase inhibitor, effectively decreasing blood lipids. This compound also inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM respectively. Deuteration, the incorporation of stable heavy isotopes, can influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Effectively decreases blood lipids
- Inhibits human SV-SMC proliferation and invasion
Medchemexpress LLC Octopamine-d3 | 111988-19-3 | 99.5% | 1 MG
Octopamine-d3 is a deuterium labeled form of Octopamine, intended for research use only. This white to off-white solid can be used as a tracer or as an internal standard for quantitative analysis.
- Deuterium labeled Octopamine
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can impact pharmacokinetic and metabolic profiles of drugs
- Appears as a white to off-white solid
Medchemexpress LLC Dopamine-d5 (hydrochloride) | 2193106-55-5 | 99.6% | 5 MG
Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). It is a white to off-white solid that acts as a catecholamine neurotransmitter. This compound is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain, playing several important roles through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis. It is suitable for research use only.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Cayman Chemical ThymIdIn-d4 5mg
An internal standard for the quantification of thymidine by GC- or LC-MS